Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique ...
WEBbavachinin. This is the first report of a synergistic glucose- and lipid-lowering effect of BVC and synthetic agonists induced by unique binding with PPAR-γ or -α. This combination may improve the efficacy and decrease the toxicity of marketed drugs for use as adjunctive therapy to treat the metabolic syndrome.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via …
WEBJun 26, 2023 · Bavachinin (BVC) is a natural small molecule from the Chinese herb Fructus Psoraleae. It exhibits numerous pharmacological effects, including anti-cancer, anti-inflammation, anti-oxidation, anti-bacterial, anti-viral, and immunomodulatory properties.
Bavachinin | C21H22O4 | CID 10337211 - PubChem
WEBBavachinin | C21H22O4 | CID 10337211 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Bavachinin selectively modulates PPAR γ and maintains bone
WEBBVC, a unique PPAR γ selective modulator, could maintain bone homeostasis, and its prodrug (BN) exhibits insulin sensitizer activity while circumventing the side effects of the TZDs, including bone loss and undesirable weight gain.
Potential metabolism determinants and drug–drug interactions of …
WEBSep 9, 2020 · Bavachinin, a natural bioactive flavanone, is reported to have many pharmacological proprieties, especially anti-osteoporosis activity. Here we aim to determine the roles of cytochrome P450s (CYP), UDP-glucuronosyltransferases (UGT), and efflux transporters in metabolism and drug–drug interactions (DDI) of bavachinin.
Bavachinin protects the liver in NAFLD by promoting …
WEBJan 1, 2024 · Here, we report bavachinin (BVC), a natural compound from traditional Chinses medicine Fructus Psoraleae, ameliorates NAFLD in hamsters. In the meanwhile, BVC promotes liver regeneration in vitro and in vivo. Taking the advantage of CC-ABPP technology, PCNA is proven to be the target of BVC.
Bavachinin protects the liver in NAFLD by promoting ... - PubMed
WEBBavachinin (BVC) is proven to possess liver-protecting effect against NAFLD, but its mechanism is still blurry. Objectives: With the use of Click Chemistry-Activity-Based Protein Profiling (CC-ABPP) technology, this study aims to identify the target of BVC, and investigate the mechanism by which BVC exerts its liver-protecting effect.
Treatment of allergic inflammation and hyperresponsiveness by …
WEBSep 9, 2013 · Bavachinin is a natural small molecule from Chinese herb Fructus Psoraleae. It has been suggested to have an anti-inflammatory function. Recently, it has been reported that Bavachinin has anti-tumor activity.
Bavachinin exhibits antitumor activity against non-small cell lung ...
WEBJul 11, 2019 · Bavachinin (BNN), one of the main active ingredients of Psoraleacorylifolia, can activate peroxisome proliferator-activated receptor γ (PPARγ). PPARγ has become a promising therapeutic target in cancer. The aim of the present study was to explore the antitumor effects of BNN in non-small cell lung cancer (NSCLC).
Treatment of allergic inflammation and hyperresponsiveness by
WEBSep 9, 2013 · Using IL-4-green fluorescent protein (GFP) reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production,...