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WEBLupus Science & Medicine® is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. An official journal of the Lupus Foundation of America (LFA), which is dedicated to advancing the science and medicine of lupus while offering support to ...
Effects of systemic lupus erythematosus on the brain: a systematic ...
WEBBackground Cognitive dysfunction (CD) is highly prevalent in systemic lupus erythematosus (SLE), yet the underlying mechanisms are poorly understood. Neuroimaging utilising advanced MRI metrics may yield mechanistic insights. We conducted a systematic review of neuroimaging studies to investigate the relationship between structural and diffusion MRI metrics and CD in SLE. Methods We ...
Clinical trial outcomes for SLE: what we have and what we need
WEBThe paradigm of drug approval in SLE currently relies on successful large phase III randomised controlled trials and a set of primary, secondary and additional end points. Taken together, these outcomes offer a nuanced understanding of the efficacy and safety of the investigational agent. In this review, we thoroughly examine the main outcomes used in SLE trials and highlight unmet ...
Characterisation and outcomes of different subsets of low disease ...
WEB6 days ago · Objectives The lupus low disease activity state (LLDAS) allows for certain clinical and/or serological activity of SLE, provided overall disease activity does not exceed predefined cut-offs. This study aimed to evaluate the outcomes of patients who achieved LLDAS with clinical activity, serological activity only or neither clinical nor serological activity. Methods Patients with SLE enrolled ...
Table of contents | Lupus Science & Medicine
WEBOriginal research: Generation of evidence supporting the content validity of SF-36, FACIT-F, and LupusQoL, and novel patient-reported symptom items for use in patients with systemic lupus erythematosus (SLE) and SLE with lupus nephritis (LN) Rebecca Williams-Hall, Pamela Berry, Nicola Williamson, Melissa Barclay, Anna Roberts, Adam Gater, Chloe ...
Global consensus building and prioritisation of fundamental lupus ...
WEBObjective Lupus is a complex, heterogeneous autoimmune disease that has yet to see significant progress towards more timely diagnosis, improved treatment options for short-term and long-term outcomes, and appropriate access to care. The Addressing Lupus Pillars for Health Advancement (ALPHA) project is the first step in establishing global consensus and developing concrete strategies to ...
About | Lupus Science & Medicine - Lupus Science & Medicine
WEBLupus Science & Medicine® is a global, peer reviewed, open access online journal that provides a central point for publication of basic, clinical, translational, and epidemiological studies of all aspects of lupus and related diseases. The journal publishes research on lupus from fields including, but not limited to: rheumatology, dermatology ...
Lupus spectrum ambiguity has long-term negative implications for ...
WEBLupus is a complex disease that is often difficult to diagnose. Risks of diagnostic delays include non-specific signs and symptoms that mimic other diseases and a lack of diagnostic criteria and referral pathways for non-specialists. To address these issues, we convened a series of virtual meetings with members of our Addressing Lupus Pillars for Health Advancement clinical care team. Meeting ...
WEBDespite disease heterogeneity, certain goals of treatment in SLE may be applicable to all patients. These include: (1) control of disease activity, (2) prevention of disease flares, (3) minimisation of irreversible damage accrual, (4) avoidance of drug toxicity and (5) improvement of patient quality of life (QoL).
Authors | Lupus Science & Medicine - Lupus Science & …
WEBLupus Science & Medicine® is an open access journal and levies an Article Processing Charge (APC) of GBP 2,163 (exclusive of VAT for UK and EU authors). The APC for a Protocol, Brief communication or Letter is 1,082 GBP. There are no submission, colour or page charges. There is a 25% discount for articles where the corresponding author has ...