Interest in lysosomal storage diseases (LSDs) has increased significantly ... outlined the ability of Myozyme (Genzyme), recombinant human α-glucosidase, to increase survival in afflicted ...

This breakthrough could eventually lead to treatments for diseases like frontotemporal ... is a phospholipid that is located in lysosomes—the cell's garbage bins. "BMP is a co-factor for ...

These observations open the door to more in-depth investigations looking into a potential mechanistic link between TMEM106b aggregation and pathological processes in neurodegeneration,” Rothstein ...

Researchers have discovered that traumatic brain injuries (TBI) may increase the risk of developing Alzheimer’s disease. By examining both brain tissue from animal models and human samples, they ...

Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

Think back to that basic biology class you took in high school. You probably learned about organelles, those little "organs" ...

Researchers found that traumatic brain injury increases synaptic dysfunction and cognitive impairments linked to developing Alzheimer's disease. Study: Neuronal BAG3 attenuates tau ...

COLUMBUS, Ohio – Each year, about 2.5 million people suffer from traumatic brain injuries (TBI), which often increases their risk for developing Alzheimer’s disease later in life. Researchers ...

When too much partially degraded heparan sulfate accumulates inside cells in a compartment known as the lysosome ... underlying genetic causes of rare human diseases. “Drosophila also has ...

Each year, about 2.5 million people suffer from traumatic brain injuries (TBI), which often increases their risk for developing Alzheimer's disease later ... mouse models and human post-mortem ...

Each year, about 2.5 million people suffer from traumatic brain injuries (TBI), which often increases their risk of ...