MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

Ubiquitylation is a well-established signal for selective degradation by the proteasome and it is also important for sorting proteins into compartments of the endosomal–lysosomal pathway.

Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

A new process, nucleophagy, repairs damaged DNA that is particularly relevant for patients undergoing colorectal cancer ...

While new endocytosis- or autophagy-mediated TPD approaches that navigate protein targets directly to proteasomes or lysosomes are being reported, their protein targets may still be limited to ...

T he typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle ...

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

All products featured here are independently selected by our editors and writers. If you buy something through links on our site, Mashable may earn an affiliate commission. How does PS5 Slim ...

The PS5 Pro is real, which means it’s time to compare it to the PS5. What’s new with Sony’s mid-gen refresh console and what upgrades does it offer? Like the PS4 Pro before it, the PS5 Pro ...

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works. As our reviews explain, we were impressed with both consoles at launch, and over the last ...

How well does PS4 Pro stack up against the PS5? When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works. The PS5 vs PS4 Pro is an interesting ...

Justin Jefferson was in the midst of a big day against the San Francisco 49ers when he was forced to exit the game. With the Minnesota Vikings up 20-7 on the defending NFC champs, Jefferson took a ...