San Francisco 49ers face a daunting Week 17 test against Detroit Lions with injuries threatening their ability to compete.

Here are the lines, spreads and totals for all 16 games on the Week 17 slate. Football Power Index (FPI) by ESPN Analytics.

It features games on five different days, starting with the Kansas City Chiefs at Pittsburgh Steelers and Baltimore Ravens at ...

The Bills won narrowly in Week 6, the first game for Jets interim coach Jeff Ulbrich. This time around, the Bills are trying to clinch the No. 2 seed, while the Jets are once again playing out the ...

With each passing game, the NFL playoff picture rounds further into shape. Here's how the NFL playoff bracket looks after "TNF" in Week 17.

Philadelphia Eagles head coach Nick Sirianni said it's going be "tough" for quarterback Jalen Hurts to play against the Dallas Cowboys, given where he is in the concussion protocol.

The Detroit Lions have released former Pittsburgh Steelers linebacker Kwon Alexander from their active roster. Detroit hopes to bring Alexander back on their practice squad, but the team has phased ...

The betting line for Sunday’s NFC North showdown between the Green Bay Packers and Minnesota Vikings has shifted back and forth without settling on a favorite.

Miami Dolphins' Calais Campbell offered a message to his team through the media before the Week 17 matchup versus the ...

Netflix's debut NFL broadcasts on Christmas Day received positive reviews and record streaming ratings but still attracted ...

Eagles head coach Nick Sirianni heavily indicates that Kenny Pickett will be his starting quarterback in Week 17 ...

The Pittsburgh Steelers will watch a weekend slate of football as they prepare for the Cincinnati Bengals in Week 18, and it ...