Ubiquitylation is a well-established signal for selective degradation by the proteasome and it is also important for sorting proteins into compartments of the endosomal–lysosomal pathway.

Scientists at Sanford Burnham Prebys have developed a clearer picture of how crucial machinery in the human cell’s recycling process for obsolete and misshapen proteins—known as proteasomes ...

Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

In a paper published in Science Bulletin, multi-omics analyses comprising of lipidomics (439 lipids), sterolomics (22 ...

Booster Therapeutics is ready to open up a new arm of the proteasome after raising $15 million in seed funding to advance small molecules it says can degrade multiple types of harmful proteins. Rather ...

T he typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle ...

More information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a ...

Developing small molecules that activate a subset of the body’s proteasomes to degrade defective proteins could be an effective way to treat neurodegenerative diseases and other complex ...

Zhou, Q.H., Li, H.M., and Xue, D. (2011). Elimination of Paternal mitochondria through the lysosomal degradation pathway in C. elegans. Cell Research 21, 1662-1669 ...

TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several ...

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