Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway are two of the most important mechanisms to repair or remove abnormal proteins. An alteration in the function of either or both of ...

Their studies of antigen presentation pathways have led to the identification of a previously unknown pathway in which cytoplasmic proteins processed by the proteasome are then transported to the ...

RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...

PlayStation 5 Pro vs PC. Last week, my X/Twitter timeline was packed with value comparisons presented with an increasing level of mania. Is the latest Sony console so overpriced that a PC may ...

Justin Jefferson was in the midst of a big day against the San Francisco 49ers when he was forced to exit the game. With the Minnesota Vikings up 20-7 on the defending NFC champs, Jefferson took a ...

Spurs started sharper, and David Raya was forced into early saves before Arsenal fought their way into the contest, although Jurrien Timber was perhaps fortunate to avoid a straight red card for a ...

Tennessee quarterback Nico Iamaleava (8) runs the ball at the NCAA College football game between Tennessee and NC State on Saturday, Sept. 7, 2024 in Charlotte, NC. / Saul Young/News Sentinel ...

Michigan State football handled business as a heavy favorite over visiting FCS school Prairie View A&M and dominated from start to finish in a 40-0 win. MSU jumped out to a 27-0 halftime lead on ...