A new process, nucleophagy, repairs damaged DNA that is particularly relevant for patients undergoing colorectal cancer ...

Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway are two of the most important mechanisms to repair or remove abnormal proteins. An alteration in the function of either or both of ...

Using a luminogenic Proteasome-Glo substrate ... the inhibition of the autophagy-lysosome pathway with Bafilomycin A1 completely abolished the enhanced cell survival associated with loss of DBT (Fig.

CaMKII activates the HRI/eIF2α signaling pathway and inhibits the proteotoxicity induced by proteasome inhibition through ...

PlayStation 5 Pro vs PC. Last week, my X/Twitter timeline was packed with value comparisons presented with an increasing level of mania. Is the latest Sony console so overpriced that a PC may ...

Justin Jefferson was in the midst of a big day against the San Francisco 49ers when he was forced to exit the game. With the Minnesota Vikings up 20-7 on the defending NFC champs, Jefferson took a ...

Please verify your email address. For the most part, that's a good thing. Running the PS4 version on PS5, every game in the collection holds a smooth 60fps. Players ...