The Lysosome This small particle acts as the digestive tract of the living cell. Its enzymes dissolve the substances ingested by the cell and under certain circumstances can dissolve the cell itself ...

Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

Ubiquitylation is a well-established signal for selective degradation by the proteasome and it is also important for sorting proteins into compartments of the endosomal–lysosomal pathway.

In a paper published in Science Bulletin, multi-omics analyses comprising of lipidomics (439 lipids), sterolomics (22 ...

Booster Therapeutics is ready to open up a new arm of the proteasome after raising $15 million in seed funding to advance small molecules it says can degrade multiple types of harmful proteins. Rather ...

T he typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle ...

More information: Jin Ju Lim et al, Pharmacological inhibition of USP14 delays proteostasis-associated aging in a ...

Developing small molecules that activate a subset of the body’s proteasomes to degrade defective proteins could be an effective way to treat neurodegenerative diseases and other complex ...

TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several ...

OLED vs Mini-LED is the biggest battle in TV world. If you want one of the best TVs, it's going to come down to one of these display technologies. Both have their pros and cons, which can make it ...

This story has been updated throughout with more details as the story has developed. We will continue to do so as the case and dispute are ongoing. The world of WordPress, one of the most popular ...