This review explores the role of lysosomal stress in pancreatic diseases, particularly diabetes mellitus. Lysosomes, crucial ...

Think back to that basic biology class you took in high school. You probably learned about organelles, those little “organs” ...

11.3. The Advisory Committee recommended that avalglucosidase alfa for the treatment of late onset Pompe disease be funded with a medium priority.

POLK expression in neurons and report an important observation that POLK exhibits an age-dependent change in subcellular localization, from the nucleus in young tissue to the cytoplasm in old tissue.

A common drug used to treat glaucoma has shown promise for neurodegenerative disease. The drug was able to prevent the ...

It is comparatively easy to tell a cell's state of health: On their surface, cells present fragments of almost all the proteins they contain inside. This means the immune system can directly recognize ...

MIPLYFFA has also been shown to reduce unesterified cholesterol in the lysosomes of human NPC fibroblasts. The clinical significance of these findings is not fully understood. MIPLYFFA was granted ...

Lucy’s discovery transformed our understanding of human origins. Don Johanson, who unearthed the Australopithecus afarensis ...

A new microscope is capable of live imaging of biological processes in such detail that moving protein complexes are visible.

The TOC (Translocon at the Outer envelope of Chloroplasts)-TIC (Translocon at the Inner envelope of Chloroplasts) ...