Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

Recent studies in mice suggest that how the egg cells hold onto and get rid of their proteins may be key to this survival. Although most proteins are renewed every few days, two studies show that some ...

CA inhibition abrogates lysosomal acidification and causes tau ... through electrophile-induced global protein ubiquitylation, proteasome activation and the formation of stress granules and ...

The ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway are two of the most important mechanisms to repair or remove abnormal proteins. An alteration in the function of either or both of ...

TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several ...

In a paper published in Science Bulletin, multi-omics analyses comprising of lipidomics (439 lipids), sterolomics (22 ...

Using a combination of imaging and single-cell RNA-seq, they characterize a population of lysosome-rich enterocytes that are essential for protein uptake. They find that the microbiome impacts the ...

CLEVELAND -- Milwaukee Bucks superstar Giannis Antetokounmpo will miss Monday night's game against the unbeaten Cleveland Cavaliers with a strained adductor muscle, another early season hiccup for ...

Victor Wembanyama had the second 5x5 game of his career while leading the San Antonio Spurs to a 106-88 victory over the Utah Jazz on Thursday night. Wembanyama had 25 points, 9 rebounds, 7 ...

Vanderbilt football got off to a slow start Saturday against Ball State. Despite giving up a touchdown on the opening drive at FirstBank Stadium, Vanderbilt's defense clamped down after that to ...