Grey’s Anatomy season 21 will premiere on Sept. 26, and an exclusive trailer teased lots of drama in store for Ellen Pompeo’s Meredith, as well as seeing two beloved characters making their return.

Grey's Anatomy has released a new look at season 21, including the return of Jesse Williams. The actor plays Dr Jackson Avery in the medical series, but he left the main cast in 2021. In the new footage, Ellen Pompeo 's Meredith Grey is certainly glad to see him back, although he's got quite the serious look on his face.

Grey's Anatomy fans need season 21, stat - especially after that spring cliffhanger where multiple doctors were fired. "I'm really excited for fans to see how we get out of the end of last season," Grey's showrunner Meg Marinis told Entertainment Weekly in September 2024.

Grey's Anatomy' has been renewed for a historic season 21. Here's what we know so far about 'Grey's Anatomy' season 21, including cast, release date and more.

Jo Wilson (Camilla Luddington) is also facing her own challenges, grappling with her pregnancy while keeping the news from Link (Chris Carmack)

If you’ve spent all summer counting down the days until Grey’s Anatomy is back on your TV, you’re in luck because new episodes are finally right around the corner. Thursday, September 26, marks the beloved show’s season 21 premiere on ABC,

As anticipation builds for the premiere of 'Grey's Anatomy' season 21 on September 26, fans were treated to an electrifying trailer that teases not only the intense storylines but also the return of two beloved characters.